Abstract: In February 2010, a randomized, blinded clinical trial to examine the health performance differences between Resflor Gold® (florfenicol and flunixin meglumine) and Baytril® (enrofloxacin) in a California calf ranch was initiated. In this 49-day study, Holstein steers were assessed for BRD in group pens after leaving hutches. A total of 655 animals qualified for the study and were randomly treated with RESFLOR GOLD (n=322) or Baytril (n=333), and both used a 5-day post treatment interval. The overall incidence of BRD in this study was 46% (655/1410). The first treatment success rate 91% (293/322) for RESFLOR GOLD is significant (p<0.0001) to Baytril 79% (262/333) for cattle in this study. There were no mortalities during this 49-day study. This study shows that RESFLOR GOLD (with a 5-day post treatment interval) outperformed Baytril in initial BRD treatment success.
Depression Scores
Respiratory Scores
The initial treatments for this study were:
First Treatment Success Rate for Cattle Treated for BRD with RESFLOR GOLD or Baytril
Average Depression and Respiratory Scores at Enrollment
Average BRD Incidence (Morbidity)
Treatment Success (Figure 1)
Mortality: There were no mortalities during this 49-day study.
Conclusion
In this field trial RESFLOR GOLD (with a 5-day post treatment
interval) outperformed Baytril as a first treatment antibiotic for bovine respiratory disease. There was no significant difference in the average respiratory scores 1.79 (Baytril) and 1.83 (RESFLOR GOLD) or the average depression scores 2.26 (Baytril) and 2.30 (RESFLOR GOLD) of animals enrolled in this study. Following initial antimicrobial treatment, a 5-day post treatment interval (PTI) was observed for all animals. During this time no animal was eligible for retreatment (unless moribund). The first treatment success rate for RESFLOR GOLD was 91%, which is significant (p<0.0001) as compared to a first treatment success rate of 79% for Baytril. This study shows that RESFLOR GOLD (with a 5-day post treatment interval) outperformed Baytril as an initial treatment for bovine respiratory disease.
IMPORTANT SAFETY INFORMATION: NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. This product contains material that can be irritating to skin and eyes. Animals intended for human consumption must not be slaughtered within 38 days treatment. This product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. A withdrawal period has not been established in pre-ruminating calves. Do not use in calves to be processed for veal. Do not use in animals that have shown hypersensitivity to florfenicol or flunixin. Not for use in animals intended for breeding purposes. The effects of florfenicol and flunixin on bovine reproductive performance, pregnancy, and lactation have not been determined. When administered according to the label directions, RESFLOR GOLD may induce a transient local reaction in the subcutaneous and underlying muscle tissue. Click here for full product information.