About Resflor

See Improvement in as Little as Six Hours

You Can’t Afford to Wait with BRD

Resflor product photos

Most cattle suffering from bovine respiratory disease (BRD) have been ill for several days before they are detected. Lungs may already have been damaged.

Irreversible damage may be minimized by simultaneous control of the bacterial infection and local inflammation3 that can cause permanent performance losses, as illustrated in a study of 2,036 feedlot calves.4 These calves were weighed at processing (five days after arrival), day 35, and at harvest, after a mean of 137 days on feed.

Association Between Lung Lesions and Reduction in ADG

Association between lung lesions and reduction in ADG

Early treatment with a fast-acting, broad-spectrum antibiotic and a non-steroidal anti-inflammatory (NSAID) can:

  • Reduce fever3 that can cause clinical depression and appetite loss
  • Control bacterial growth3 that leads to the release of bacterial toxins which cause lung damage
  • Reduce the severity of disease events that lead to irreversible lung lesions5 and lost profits

The Future of BRD Therapy

RESFLOR GOLD combines the powerful antibiotic florfenicol with the fast-acting non-steroidal anti-inflammatory drug (NSAID) flunixin meglumine.

RESFLOR GOLD is effective for the treatment of BRD associated with the economically important bacterial pathogens Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis. A single subcutaneous (SQ) injection of 6 cc per 100 pounds promotes rapid recovery.

The unique formulation of RESFLOR GOLD is better than individual doses of florfenicol and flunixin meglumine because it saves time and animal handling with the convenience of a one-dose SQ administration.

You can see improvement in just six hours.

Fever reduction illustration

Time-lapse photos were taken during an actual trial conducted at a Research Facility in Canyon, TX, on October 14, 2009.

Time for a BACTERIA-KILLING Dual-Action Therapy

Mean plasma florfenicol concentrations are above 1 µg/mL within 30 minutes in cattle treated with RESFLOR GOLD SQ injection.6

The result is a fast and powerful bacteria-killing response from florfenicol treatment.2

Mean Plasma Concentrations of Florfenicol VERSUS Time in Cattle

Mean Plasma concentrations of Florfenicol inCattle After subcutaneous administration of Resflor and Nuflor

Tissue Penetration That is Fast and Extensive

With Florfenicol:

  • Concentrations of antibiotic in lung tissue were similar to those observed in whole blood.6
  • The penetration of florfenicol was seen in all other areas of the respiratory tract including the trachea, bronchi, nasal sinuses, nares and tracheal cartilage rings.6

Lung of calf treated with C-florfenicol (RESFLOR containing radiolabelled florfenicol) embedded within a frozen carboxymethylcellulose block

Lung of calf treated with C-florfenicol (containing radiolabelled florfenicol) embedded within a frozen carboxymethylcellulose block

Autoradiograph of a 30-micron section of lung from the block pictured above

Autoradiograph of a 30-micron section of lung from the block pictured above

Cross-section of the head of a calf treated with RESFLOR formulated with C-florfenicol

Cross-section of the head of a calf treated with 14C-florfenicol

Autoradiograph of a 30-micron section of the tissue from the block pictured above

Autoradiograph of a 30-micron section of the tissue from the block pictured above

color key

Time for a FEVER-REDUCING Dual-Action Therapy

A Comparison of Florfenicol-Flunixin Meglumine versus Tulathromycin for the Treatment of Undifferentiated Fever in Fall-placed Feedlot Calves

Highlights of a Controlled Study* Published in Veterinary Therapeutics Vol. 10, No. 1-2, Spring-Summer 2009

Overview

The purpose of this study was to compare the efficacy of a new combination drug, florfenicol-flunixin meglumine [Resflor®], with tulathromycin [Draxxin®] for initial treatment of undifferentiated fever (UF) in fall-placed calves that received metaphylactic tilmicosin [Micotil®] on arrival at the feedlot.

Results

  • There were no statistically significant differences between florfenicol-flunixin and tulathromycin in first, second, or third UF relapse rates.
  • Calves treated with florfenicol-flunixin had a lower crude case fatality rate (P=0.0447) than calves treated with tulathromycin.

Investigators: Joyce Van Donkersgoed, DVM, MVS; Janice Berg, DVM; Steven Hendrick, DVM, DVSc

The Future of BRD Therapy in a Single SQ Dose

  • Fast acting
  • Long acting
  • Kills bacteria
  • Reduces fever
  • Visible improvement in 6 hours
  • Helps preserve profits

For subcutaneous use in beef and non-lactating dairy cattle only. Not for use in female dairy cattle 20 months of age or older or in calves to be processed for veal. The effects of florfenicol and flunixin meglumine on bovine reproductive performance, pregnancy and lactation have not been determined. When administered according to the label directions, RESFLOR GOLD may induce a transient local reaction in the subcutaneous and underlying muscle tissue.

REFERENCES

  1. Exhibits bacterial activity against some strains of Mannheimia haemolytica and Histophilus somni.
  2. The correlation between in vitro susceptibility data and clinical effectiveness is unknown.
  3. Lekeux P. Bovine respiratory disease complex: an European perspective. Bovine Practitioner 1995: vol 29, 71-75.
  4. Thompson PN et al. J. Anim Sci 2006; 84:488-498.
  5. Weingarten A. Simmons RD, de Haas V et al.: The Efficacy of Resflor, A New Therapeutic Agent for the Treatment of Bovine Respiratory Disease. Presentation at The XXIV World Buiatrics Congress, Nice, France 2006 (proceedings published by the Gloyd Group, Wilmington, Deleware).
  6. Wrzesinski, Chris. Comparison of Florfenicol-Flunixin/2-Pyrrolidone/Triacetin Formulation to Resflor/n-methyl-2-Pyrrolidone Formulation in a Single Dose Bioequivalence, Crossover Study of Florfenicol and Flunixin in Cattle. SPRI Study No. 06244.

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