Most cattle suffering from bovine respiratory disease (BRD) have been ill for several days before they are detected. Lungs may already have been damaged.
Irreversible damage may be minimized by simultaneous control of the bacterial infection and local inflammation3 that can cause permanent performance losses, as illustrated in a study of 2,036 feedlot calves.4 These calves were weighed at processing (five days after arrival), day 35, and at harvest, after a mean of 137 days on feed.
Association Between Lung Lesions and Reduction in ADG
Early treatment with a fast-acting, broad-spectrum antibiotic and a non-steroidal anti-inflammatory (NSAID) can:
RESFLOR GOLD combines the powerful antibiotic florfenicol with the fast-acting non-steroidal anti-inflammatory drug (NSAID) flunixin meglumine.
RESFLOR GOLD is effective for the treatment of BRD associated with the economically important bacterial pathogens Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis. A single subcutaneous (SQ) injection of 6 cc per 100 pounds promotes rapid recovery.
The unique formulation of RESFLOR GOLD is better than individual doses of florfenicol and flunixin meglumine because it saves time and animal handling with the convenience of a one-dose SQ administration.
You can see improvement in just six hours.
Time-lapse photos were taken during an actual trial conducted at a Research Facility in Canyon, TX, on October 14, 2009.
Mean plasma florfenicol concentrations are above 1 µg/mL within 30 minutes in cattle treated with RESFLOR GOLD SQ injection.6
The result is a fast and powerful bacteria-killing response from florfenicol treatment.2
Mean Plasma Concentrations of Florfenicol VERSUS Time in Cattle
Lung of calf treated with C-florfenicol (containing radiolabelled florfenicol) embedded within a frozen carboxymethylcellulose block
Autoradiograph of a 30-micron section of lung from the block pictured above
Cross-section of the head of a calf treated with 14C-florfenicol
Autoradiograph of a 30-micron section of the tissue from the block pictured above
A Comparison of Florfenicol-Flunixin Meglumine versus Tulathromycin for the Treatment of Undifferentiated Fever in Fall-placed Feedlot Calves
Highlights of a Controlled Study* Published in Veterinary Therapeutics Vol. 10, No. 1-2, Spring-Summer 2009
The purpose of this study was to compare the efficacy of a new combination drug, florfenicol-flunixin meglumine [Resflor®], with tulathromycin [Draxxin®] for initial treatment of undifferentiated fever (UF) in fall-placed calves that received metaphylactic tilmicosin [Micotil®] on arrival at the feedlot.
Investigators: Joyce Van Donkersgoed, DVM, MVS; Janice Berg, DVM; Steven Hendrick, DVM, DVSc
For subcutaneous use in beef and non-lactating dairy cattle only. Not for use in female dairy cattle 20 months of age or older or in calves to be processed for veal. The effects of florfenicol and flunixin meglumine on bovine reproductive performance, pregnancy and lactation have not been determined. When administered according to the label directions, RESFLOR GOLD may induce a transient local reaction in the subcutaneous and underlying muscle tissue.
For full product details, download the product information sheet
IMPORTANT SAFETY INFORMATION: NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. This product contains material that can be irritating to skin and eyes. Animals intended for human consumption must not be slaughtered within 38 days treatment. This product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. A withdrawal period has not been established in pre-ruminating calves. Do not use in calves to be processed for veal. Do not use in animals that have shown hypersensitivity to florfenicol or flunixin. Not for use in animals intended for breeding purposes. The effects of florfenicol and flunixin on bovine reproductive performance, pregnancy, and lactation have not been determined. When administered according to the label directions, RESFLOR GOLD may induce a transient local reaction in the subcutaneous and underlying muscle tissue. Click here for full product information.